Liverpool will play Serie A side Atalanta in the Europa League quarter-finals while Bundesliga leaders Bayer Leverkusen take on West Ham United after the draw was held at UEFA's headquarters in Nyon on Friday.
AC Milan are looking to win the trophy for the first time and they will face last season's beaten finalists AS Roma in an all-Italian clash.
Benfica were drawn against French side Olympique de Marseille and the winners of that quarter-final will face either Liverpool or Atalanta in the semis.
The other semi-final will see an Italian side, Milan or Roma, come up against Bayer Leverkusen or West Ham.
West Ham won last season's Conference League and reached the semi-final of the Europa League in 2022, but they face a tough task against Leverkusen. The German side are unbeaten across 37 games in all competitions this season.
Leverkusen, 10 points clear in the Bundesliga, kept their unbeaten run going and scraped through to the quarter-finals on Thursday when they came from 2-0 down to beat Qarabag 3-2, ensuring a 5-4 aggregate win.
Quarter final 1: AC Milan v AS Roma
Quarter final 2: Liverpool v Atalanta
Quarter final 3: Bayer Leverkusen v West Ham United
Quarter final 4: Benfica v Olympique de Marseille
* Team drawn first hosts the first leg
* First legs: April 11
* Second legs: April 18
Semi-final 1: Benfica/Marseille v Liverpool/Atalanta
Semi-final 2: AC Milan/Roma v Bayer Leverkusen/West Ham
* Team drawn first hosts the first leg
* First legs: May 2
* Second legs: May 9
Aviva Stadium, Dublin: May 22
