Midfielders Franck Ribery and James Rodriguez will miss Bayern Munich's Bundesliga trip to Freiburg on Sunday, coach Jupp Heynckes said on Friday.
France's Ribery has an intestinal infection while Colombia's James Rodriguez has been struggling with a calf problem.
"I still have to think about the line-up," Heynckes said.
Left-back David Alaba was able to train normally after a minor knee complaint.
Bayern are 19 points clear and coasting to a sixth straight Bundesliga title, but they did draw 0-0 at home to Hertha Berlin last weekend.
Heynckes began his fourth stint in charge of Bayern at home to Freiburg in October and won 5-0, but is expecting a different challenge in the Black Forest.
"It's a tough game," Heynckes said. "The boys are not only fit, but strong and aggressive because we have to be wide awake."
