Galatasaray were stunned in the Turkish league on Sunday evening by a 3-0 loss to Akhisarspor played at Akhisar Arena in the Aegean region city of the same name.
Akhisarspor found three goals in the second half to earn their first win in the league, bucking a five-match winless streak to start the season.
Galatasaray wasted a chance to take the lead in late first half, as Garry Rodrigues missed the penalty kick.
Akhisarspor's first half goal was also disallowed with offside after the referee checked with the Video Assistant Referee (VAR) system.
Tireless Dutch winger Elvis Manu was the key player for his team, breaking the deadlock in the 51st minute and then winning a penalty kick for his team in the 80th minute.
Guray Vural scored the penalty to make the score 2-0 for Akhisar, and Mustafa Yumlu added one more to the tally after goalkeeper Fernando Muslera's mistake in the 84th minute.
Galatasaray suffered their second loss of the season and stayed with 12 points to lose the leaders' spot to Medipol Basaksehir, who drew 0-0 with Bursaspor to move up to 13 points.
Week six of the Spor Toto Super Lig will conclude on Monday evening with a derby match, as Besiktas will host Fenerbahce at Istanbul's Vodafone Arena.