Manchester City midfielder Kevin De Bruyne has been ruled out for at least a month after suffering a knee injury against Fulham in the League Cup, British media reported on Friday.
The Belgian playmaker was substituted in the 85th minute of City's 2-0 win over Fulham at the Etihad Stadium on Thursday after opposing defender Timothy Fosu-Mensah landed heavily on his left knee.
De Bruyne, who played a pivotal role in City's record-breaking Premier League title triumph last term, has already spent six weeks on the sidelines this season.
The 27-year-old is now likely to miss City's next six matches, including a league clash against local rivals Manchester United on Nov. 11.
Pep Guardiola's City, currently top of the table with 26 points from 10 matches, host Southampton on Sunday.