Manchester City striker Gabriel Jesus and defender Kyle Walker have tested positive for COVID-19, the Premier League club said on Friday.
Two other City staff members have also tested positive for the novel coronavirus, and all four are self-isolating.
"Everyone at the club wishes our colleagues a speedy recovery over the Christmas period ahead of their return to work, training and competition," City said in a statement.
City, eighth in the league table, host Newcastle United on Saturday before visiting Everton on Monday.