Manchester United was paired with Real Betis in the round of 16 of the Europa League on Friday, giving the 2017 champions another Spanish opponent after eliminating Barcelona.
Man United will host the first leg at Old Trafford on March 9.
The last Ukrainian team left in this season's European competitions, Shakhtar Donetsk, was drawn to face Feyenoord. Shakhtar will host the first leg in neighboring Poland because of the Russian military invasion of Ukraine.
Premier League leader Arsenal will face Sporting Lisbon, with the first leg played in Portugal.
Arsenal was seeded in the draw because it was among the eight winners of the Europa League groups, and those teams play the second leg at home. Unseeded teams hosting the first leg came through the playoff round, which involved Europa League group runners-up and teams which placed third in a Champions League group.
Juventus was paired with Freiburg and six-time champion Sevilla will be at home first against Fenerbahçe. Union Berlin will have a reunion with Union Saint-Gilloise after they also met twice in the group stage.
Roma, coached by Jose Mourinho, will play Real Sociedad, while Bayer Leverkusen was paired with Ferencvaros.
The Europa League final will be played in Budapest on May 31 at Puskas Arena.
