The SpaceX Polaris Dawn mission, which made history when its crew conducted the first ever spacewalk by non-government astronauts, is returning to Earth on Sunday.
Splashdown is scheduled to take place at approximately 3:36 am Eastern Time (0736 GMT) off the coast of Dry Tortugas, Florida.
A live webcast will be carried by SpaceX starting around an hour beforehand.
The four-member team led by fintech billionaire Jared Isaacman launched Tuesday from the Kennedy Space Center, quickly journeying deeper into the cosmos than any humans in the past half century as they ventured into the dangerous Van Allen radiation belt.
They hit a peak altitude of 870 miles (1,400 kilometers) -- more than three times higher than the International Space Station, and the furthest humans had ever traveled from Earth since the Apollo missions to the Moon.
Then on Thursday, with their Dragon spacecraft's orbit brought down to 434 miles, Isaacman swung open the hatch and climbed out into the void, gripping a structure called "Skywalker" as a breathtaking view of Earth unfolded before him.
"SpaceX, back at home we all have a lot of work to do, but from here, Earth sure looks like a perfect world," he told mission control in Hawthorne, California, where teams erupted in applause.
He went back inside after a few minutes and was replaced by a second astronaut, SpaceX engineer Sarah Gillis, who, like Isaacman, performed a series of mobility tests on SpaceX's sleek, next-generation suits.
Since Dragon doesn't have an airlock, the entire crew were exposed to the vacuum of space. Mission pilot Scott Poteet and SpaceX engineer Anna Menon remained strapped in throughout as they monitored vital support systems.
It marked a "giant leap forward" for the commercial space industry, said NASA chief Bill Nelson, as well as another triumphant achievement for SpaceX.
Though the company was only founded in 2002, it has outpaced its legacy competitors thanks in large part to founder Elon Musk's vast fortune and zeal to begin the colonization of Mars.