U.S. leaders urgently called on Americans to wear masks and threatened even more drastic stay-at-home orders after deaths from the coronavirus set a single-day record, with two people dying every minute.
More than 213,830 new cases and 2,861 deaths were reported on Thursday, according to a Reuters tally of official data, with several experts projecting the death toll will soon surpass 3,000 per day.
President-elect Joe Biden promised a new national strategy that will impose mask mandates where he will have authority, such as federal buildings and for interstate travel, once he takes over for departing President Donald Trump on Jan. 20.
Beyond the mandate, he urged people to voluntarily wear masks, a novel approach after lax public discipline to date and Trump's own timid endorsement of mask-wearing.
"On the first day I'm inaugurated ... I'm going to ask the public for 100 days to mask, just 100 days to mask, not forever, 100 days," Biden told CNN in an interview Thursday. "And I think we'll see a significant reduction if we incur that - if that occurs, with vaccinations and masking, to drive down the numbers considerably."
Two promising vaccine candidates could soon receive emergency use authorization from the U.S. Food and Drug Administration, and some 20 million Americans could be vaccinated this year, Commissioner Stephen Hahn told Reuters in an interview on Friday.
As soon as the FDA approves a vaccine, "I will be first in line and I will encourage my family to take this vaccine," Hahn said.
Biden also told CNN he would be happy to get vaccinated publicly, as former presidents Bill Clinton, George W. Bush and Barack Obama have pledged, in order to boost public confidence and pursuade vaccine skeptics.
Other public figures have followed, including best-selling novelist Stephen King.
"As a kid of 5 or 6, I lined up with other little people to get the Polio Vaccine. As a man of 73, I'll line up for the Covid Vaccine as soon as I'm told it's time," King said on Twitter.
Dr. Anthony Fauci, a member of the White House coronavirus task force, said Friday he expected to see another surge in coronavirus infections two or three weeks after the Nov. 26 Thanksgiving holiday, when many Americans traveled to visit family, and feared Christmas shopping and parties would fuel another spike.
"We're in a very precarious situation right now. There certainly is light at the end of the tunnel with a vaccine, but we're not there yet. So we really have to intensify our public health measures to try and blunt this trajectory," Fauci, director of the National Institute of Allergy and Infectious Diseases, told NBC's "Today" show.
Fauci said he has accepted Biden's offer to be his chief medical adviser, as well as keep his current position.
"I said yes right on the spot," Fauci said, while also endorsing Biden's 100-day plea.
As U.S. cases since the start of the pandemic surpassed 14 million on Thursday and more than 100,000 people were hospitalized, California Governor Gavin Newsom said he would impose strict new stay-at-home orders to be triggered on a region-by-region basis when less than 15 percent ICU capacity is available.
Washington University's Institute for Health Metrics and Evaluation now projects nearly 539,000 COVID-19 deaths by April 1, almost double the current death toll since the pandemic began, even with the life-saving effects of vaccines.
But 66,000 people could be saved if the share of Americans wearing masks in public rose to 95% in the next week, the institute said.
Globally, the pandemic has killed more than 1.5 million people.