Its brightest period was in the 2nd century AD. Kremna came under the rule of the Lydians in the 6th century BC, the Persians in 546 BC, and then Alexander the Great in 333 BC, falling under Macedonian rule. Subsequently, it was ruled by Antigonus, Seleucids, the Kingdom of Pergamon, Rome in 60 BC, Galatia in 36 BC, and again by Rome in 25 BC. Following the fragmentation of the Roman Empire, it came under the rule of the Eastern Roman (Byzantine) Empire.
