The church, which features wall paintings, stonework and inscriptions in Karamanlı -- Turkish written using the Greek alphabet -- is one of İncesu's important historical structures.
Its restoration, which began in 2021, was completed last year. The work preserved the building's original fabric as well as its frescoes, reliefs, carvings and other features, according to the Kayseri Metropolitan Municipality.
Tayfun Talaslı, head of the municipality's Historical Buildings and Museums Branch Directorate, said the church was used as a place of worship until the 1923 population exchange between Greece and Türkiye.
It was later used for different purposes, including as a military warehouse, archive, theater hall and vocational school, he told Anadolu.
The museum's display and arrangement work is more than 80% complete, and officials plan to open it soon.
Talaslı said the restoration was based on archival photographs, documents and oral histories of people who had lived in the area.
"We will create a museum on the ground floor, where we will tell about the city's tangible and intangible cultural heritage," he said.
Visitors will be able to learn about İncesu's history, architecture, notable figures, archaeology, gastronomy, agriculture and grape production.
They will also see artifacts, including ceramics unearthed at the nearby Orensehir archaeological site, Talaslı said.