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15 pandemic diseases that changed history

Humanity has faced many calamities and diseases throughout history. Over 2500 years, millions of lives have been lost due to pandemic diseases. These diseases not only changed history but also impacted fundamental areas such as the economy, health, and social thought. Pandemics have been historical factors that have wounded societies and led to significant population losses.

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541 - Justinian Plague: This plague, originating in Egypt, spread through Palestine. It disrupted the plans of Byzantine Emperor Justinian to reunite the Roman Empire. During the Justinian Plague, more than 50 million people died. This number accounted for over twenty-five percent of the existing world population at the time.