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15 pandemic diseases that changed history

Humanity has faced many calamities and diseases throughout history. Over 2500 years, millions of lives have been lost due to pandemic diseases. These diseases not only changed history but also impacted fundamental areas such as the economy, health, and social thought. Pandemics have been historical factors that have wounded societies and led to significant population losses.

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1665 - Great Plague of London: The second major plague pandemic killed one-fifth of London's population. As the death toll rose, mass graves emerged, and aristocrats fled to the countryside. The people of London brutally slaughtered hundreds of thousands of cats and dogs, which were believed to be the likely cause of the disease and the spread along the ports lining the Thames River.