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15 pandemic diseases that changed history

Humanity has faced many calamities and diseases throughout history. Over 2500 years, millions of lives have been lost due to pandemic diseases. These diseases not only changed history but also impacted fundamental areas such as the economy, health, and social thought. Pandemics have been historical factors that have wounded societies and led to significant population losses.

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250 - Plague of Cyprus: Unlike symptoms of other pandemics, gangrene appeared on the hands and feet in this plague outbreak. The plague spread so extensively that it lasted for approximately three centuries. The pandemic that reached England in 444 AD changed the existing political balance. The English sought help from the Saxons, who then took control of the island.